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Attention Score in Context
| Title |
Variations in DEPDC5 gene and its association with chronic hepatitis C virus infection in Saudi Arabia
|
|---|---|
| Published in |
BMC Infectious Diseases, December 2014
|
| DOI | 10.1186/s12879-014-0632-y |
| Pubmed ID | |
| Authors |
Mashael R Al-Anazi, Sabine Matou-Nasri, Ayman A Abdo, Faisal M Sanai, Mohammed Q Khan, Ali Albenmousa, Hamad I Al-Ashgar, Nisreen Z Khalaf, Mohammed N Al-Ahdal, Ahmed A Al-Qahtani |
| Abstract |
BackgroundVariations at DEPDC5 gene have been recently reported as genetic markers associated with hepatocellular carcinoma (HCC) progression in chronic HCV-infected patients. This study was conducted to assess the association of DEPDC5 variants with advanced liver cirrhosis and HCC development among chronic HCV-infected patients in Saudi Arabian population.MethodsSix-hundred and one HCV-infected patients were genotyped for DEPDC5 polymorphisms (rs1012068 and rs5998152), in comparison with 592 non-infected healthy control subjects. The allelic frequency and genotype distribution of both DEPDC5 polymorphisms were determined followed by haplotype frequency estimation and multiple logistic regression analysis.ResultsThe frequency of the risk alleles of both rs1012068 and rs5998152 was shown to be more in healthy control subjects than in patients (p =0.0001, OR =0.704, CI =0.591-0.839; p =0.002, OR =0.761, CI =0. 0.639-0.907, respectively). Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p =0.0104) and CT for SNP rs5998152 (OR =1.932; 95% CI 1.276-2.925; p =0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively. The data also revealed that subjects with the T allele of both SNPs appeared to have a lower susceptibility to HCV-related cirrhosis/HCC than those with the G allele of rs1012068 (p¿=¿0.038, OR¿=¿1.353, 95 % CI 1.017-1.800) and C allele of rs5998152 (p¿=¿0.043, OR¿=¿1.342, 95 % CI 1.010-1.784). Haplotype analysis showed that a combination of T-T alleles of rs1012068 and rs5998152 was significantly associated with liver cirrhosis (frequency =71.3% and p =0.027) and with cirrhosis/HCC (frequency =71.4% and P =0.045). Also, multiple logistic regression analysis showed that rs5998152 (OR =2.844, 95% CI 1.333-6.069 and p =0.007), rs1012068 (OR =2.793, 95% CI 1.316-5.928 and p =0.010), age (OR =1.029, 95% CI 1.001-1.057 and p =0.041) and HCV genotypes (OR =0.247, 95% CI 0.097-0.630 and p =0.003) were independently associated with chronicity of HCV infection.ConclusionGenetic variations in DEPDC5 gene region may influence HCV-associated liver cirrhosis and/or HCC development. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 5 | 45% |
| Kuwait | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 91% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 38% |
| Student > Master | 2 | 25% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 38% |
| Medicine and Dentistry | 2 | 25% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2015.
All research outputs
#4,710,376
of 25,844,815 outputs
Outputs from BMC Infectious Diseases
#1,612
of 8,716 outputs
Outputs of similar age
#59,827
of 361,629 outputs
Outputs of similar age from BMC Infectious Diseases
#33
of 188 outputs
Altmetric has tracked 25,844,815 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,716 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,629 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.