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Invariance and plasticity in the Drosophila melanogastermetabolomic network in response to temperature

Overview of attention for article published in BMC Systems Biology, December 2014
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Invariance and plasticity in the Drosophila melanogastermetabolomic network in response to temperature
Published in
BMC Systems Biology, December 2014
DOI 10.1186/s12918-014-0139-6
Pubmed ID

Ramkumar Hariharan, Jessica M Hoffman, Ariel S Thomas, Quinlyn A Soltow, Dean P Jones, Daniel EL Promislow


BackgroundMetabolomic responses to extreme thermal stress have recently been investigated in Drosophila melanogaster. However, a network level understanding of metabolomic responses to longer and less drastic temperature changes, which more closely reflect variation in natural ambient temperatures experienced during development and adulthood, is currently lacking. Here we use high-resolution, non-targeted metabolomics to dissect metabolomic changes in D. melanogaster elicited by moderately cool (18°C) or warm (27°C) developmental and adult temperature exposures.ResultsWe find that temperature at which larvae are reared has a dramatic effect on metabolomic network structure measured in adults. Using network analysis, we are able to identify modules that are highly differentially expressed in response to changing developmental temperature, as well as modules whose correlation structure is strongly preserved across temperature.ConclusionsOur results suggest that the effect of temperature on the metabolome provides an easily studied and powerful model for understanding the forces that influence invariance and plasticity in biological networks.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Portugal 1 2%
Denmark 1 2%
Unknown 61 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 35%
Student > Bachelor 8 12%
Researcher 8 12%
Professor > Associate Professor 8 12%
Other 4 6%
Other 7 11%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 43%
Biochemistry, Genetics and Molecular Biology 13 20%
Environmental Science 3 5%
Computer Science 3 5%
Medicine and Dentistry 3 5%
Other 8 12%
Unknown 7 11%