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Invariance and plasticity in the Drosophila melanogastermetabolomic network in response to temperature

Overview of attention for article published in BMC Systems Biology, December 2014
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1 tweeter

Citations

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64 Mendeley
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2 CiteULike
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Title
Invariance and plasticity in the Drosophila melanogastermetabolomic network in response to temperature
Published in
BMC Systems Biology, December 2014
DOI 10.1186/s12918-014-0139-6
Pubmed ID
Authors

Ramkumar Hariharan, Jessica M Hoffman, Ariel S Thomas, Quinlyn A Soltow, Dean P Jones, Daniel EL Promislow

Abstract

BackgroundMetabolomic responses to extreme thermal stress have recently been investigated in Drosophila melanogaster. However, a network level understanding of metabolomic responses to longer and less drastic temperature changes, which more closely reflect variation in natural ambient temperatures experienced during development and adulthood, is currently lacking. Here we use high-resolution, non-targeted metabolomics to dissect metabolomic changes in D. melanogaster elicited by moderately cool (18°C) or warm (27°C) developmental and adult temperature exposures.ResultsWe find that temperature at which larvae are reared has a dramatic effect on metabolomic network structure measured in adults. Using network analysis, we are able to identify modules that are highly differentially expressed in response to changing developmental temperature, as well as modules whose correlation structure is strongly preserved across temperature.ConclusionsOur results suggest that the effect of temperature on the metabolome provides an easily studied and powerful model for understanding the forces that influence invariance and plasticity in biological networks.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Portugal 1 2%
Denmark 1 2%
Unknown 60 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 36%
Student > Bachelor 8 13%
Researcher 8 13%
Professor > Associate Professor 8 13%
Other 4 6%
Other 7 11%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 44%
Biochemistry, Genetics and Molecular Biology 13 20%
Environmental Science 3 5%
Computer Science 3 5%
Medicine and Dentistry 3 5%
Other 8 13%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2014.
All research outputs
#11,153,845
of 12,537,999 outputs
Outputs from BMC Systems Biology
#919
of 1,056 outputs
Outputs of similar age
#232,387
of 285,211 outputs
Outputs of similar age from BMC Systems Biology
#69
of 81 outputs
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