Title |
Identification of signaling pathways in early mammary gland development by mouse genetics
|
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Published in |
Breast Cancer Research, March 2004
|
DOI | 10.1186/bcr776 |
Pubmed ID | |
Authors |
Gertraud W Robinson |
Abstract |
The mammary gland develops as an appendage of the ectoderm. The prenatal stage of mammary development is hormone independent and is regulated by sequential and reciprocal signaling between the epithelium and the mesenchyme. A number of recent studies using human and mouse genetics, in particular targeted gene deletion and transgenic expression, have identified some of the signals that control specific steps in development. This process involves cell specification and proliferation, reciprocal tissue interactions and cell migration. Since some of these events are recapitulated during tumorigenesis, an understanding of these signaling pathways may contribute to the development of targeted therapies and novel drugs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 19% |
Student > Bachelor | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Student > Master | 4 | 13% |
Professor > Associate Professor | 3 | 9% |
Other | 6 | 19% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 47% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Medicine and Dentistry | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
Unknown | 5 | 16% |