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Mendeley readers
Attention Score in Context
| Title |
Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts
|
|---|---|
| Published in |
Journal of Hematology & Oncology, December 2014
|
| DOI | 10.1186/s13045-014-0089-x |
| Pubmed ID | |
| Authors |
Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J Rogers, Ramon V Tiu |
| Abstract |
BackgroundThe presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS. We previously reported the presence of bone marrow (BM) RS in Sf3b1 heterozygous (Sf3b1 +/¿) mice which are rarely found in mouse models of MDS. Sf3b1 +/¿ mice were originally engineered to study the interaction between polycomb genes and other proteins.MethodsWe used routine blood tests and histopathologic analysis of BM, spleen, and liver to evaluate the hematologic and morphologic characteristics of Sf3b1 +/¿ mice in the context of MDS by comparing the long term follow-up (15 months) of Sf3b1 +/¿ and Sf3b1 +/+ mice. We then performed a comprehensive RNA-sequencing analysis to evaluate the transcriptome of BM cells from Sf3b1 +/¿ and Sf3b1 +/+ mice.Results Sf3b1 +/¿ exhibited macrocytic anemia (MCV: 49.5¿±¿1.6 vs 47.2¿±¿1.4; Hgb: 5.5¿±¿1.7 vs 7.2¿±¿1.0) and thrombocytosis (PLTs: 911.4¿±¿212.1 vs 878.4¿±¿240.9) compared to Sf3b1 +/+ mice. BM analysis showed dyserythropoiesis and occasional RS in Sf3b1 +/¿ mice. The splenic architecture showed increased megakaryocytes with hyperchromatic nuclei, and evidence of extramedullary hematopoiesis. RNA-sequencing showed higher expression of a gene set containing Jak2 in Sf3b1 +/¿ compared to Sf3b1 +/+.ConclusionsOur study indicates that Sf3b1 +/¿ mice manifest features of low risk MDS-RS and may be relevant for preclinical therapeutic studies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Student > Master | 5 | 15% |
| Researcher | 4 | 12% |
| Student > Bachelor | 2 | 6% |
| Student > Postgraduate | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 10 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 35% |
| Agricultural and Biological Sciences | 8 | 24% |
| Medicine and Dentistry | 3 | 9% |
| Psychology | 1 | 3% |
| Unknown | 10 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2015.
All research outputs
#18,388,295
of 22,776,824 outputs
Outputs from Journal of Hematology & Oncology
#925
of 1,189 outputs
Outputs of similar age
#260,927
of 360,235 outputs
Outputs of similar age from Journal of Hematology & Oncology
#11
of 16 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,189 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.