Title |
MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination
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Published in |
Allergy, Asthma & Clinical Immunology, December 2017
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DOI | 10.1186/s13223-017-0222-9 |
Pubmed ID | |
Authors |
Stefanie Eindhoven, Jolien Levels, Margriet Huisman, Koos Ruizeveld de Winter, Virgil Dalm, Rehmat Alwani |
Abstract |
Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). We describe the case of a 67-year old man who presented with a myeloperoxidase-ANCA associated vasculitis with renal involvement and mononeuritis multiplex after seasonal influenza vaccination. He was initially treated with intravenous cyclophosphamide and high-dose prednisolone followed by maintenance treatment consisting of azathioprine and prednisolone. We hypothesize that seasonal influenza vaccination triggered a systemic immune response in a susceptible patient to develop AAV with renal involvement and vasculitic neuropathy. In general, seasonal influenza vaccinations are considered to be safe, however, clinicians should be aware of this rare phenomenon. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 33% |
United States | 2 | 33% |
United Kingdom | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 17% |
Student > Bachelor | 7 | 17% |
Other | 4 | 10% |
Researcher | 4 | 10% |
Student > Postgraduate | 3 | 7% |
Other | 10 | 24% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 38% |
Nursing and Health Professions | 2 | 5% |
Unspecified | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 33% |