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Systematic evaluation of connectivity map for disease indications

Overview of attention for article published in Genome Medicine, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

blogs
1 blog
twitter
4 X users
patent
2 patents

Citations

dimensions_citation
100 Dimensions

Readers on

mendeley
124 Mendeley
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Title
Systematic evaluation of connectivity map for disease indications
Published in
Genome Medicine, December 2014
DOI 10.1186/s13073-014-0095-1
Pubmed ID
Authors

Jie Cheng, Lun Yang, Vinod Kumar, Pankaj Agarwal

Abstract

Connectivity map data and associated methodologies have become a valuable tool in understanding drug mechanism of action (MOA) and discovering new indications for drugs. One of the key ideas of connectivity map (CMAP) is to measure the connectivity between disease gene expression signatures and compound-induced gene expression profiles. Despite multiple impressive anecdotal validations, only a few systematic evaluations have assessed the accuracy of this aspect of CMAP, and most of these utilize drug-to-drug matching to transfer indications across the two drugs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
France 1 <1%
Slovenia 1 <1%
Unknown 120 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 26%
Researcher 31 25%
Student > Doctoral Student 8 6%
Student > Bachelor 7 6%
Student > Master 6 5%
Other 19 15%
Unknown 21 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 24%
Agricultural and Biological Sciences 19 15%
Computer Science 12 10%
Medicine and Dentistry 12 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 19 15%
Unknown 28 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2021.
All research outputs
#2,378,178
of 23,100,534 outputs
Outputs from Genome Medicine
#552
of 1,449 outputs
Outputs of similar age
#35,102
of 363,019 outputs
Outputs of similar age from Genome Medicine
#24
of 69 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,449 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,019 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.