Title |
Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy
|
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Published in |
BMC Infectious Diseases, December 2014
|
DOI | 10.1186/s12879-014-0729-3 |
Pubmed ID | |
Authors |
Andrea Frustaci, Nicola Petrosillo, Marco Francone, Romina Verardo, Giuseppe Ippolito, Cristina Chimenti |
Abstract |
Dilated cardiomyopathy occurring in HIV-infected patients raises both diagnostic and therapeutic challenging problems. Indeed myocardial involvement in HIV infection has been variously attributed to several causes, including viral, toxic, nutritional and autoimmune, but no specific treatment capable to substantially improve patients¿ prognosis has been recognized so far. Hereby we describe the case of an autoimmune myocarditis manifesting with heart failure in a 39-year-old man with HIV infection. Left ventricular endomyocardial biopsy showed a lymphocytic myocarditis characterized by over-expression of HLA-DR and negative polymerase chain reaction for cardiotropic viruses. Steroid treatment was followed by recovery of cardiac dimension and function. Presence of auto-reactive myocarditis should be considered in patients with HIV-associated dilated cardiomyopathy. Its recognition by endomyocardial biopsy followed by steroid administration may result in a complete resolution of cardiac disease. |
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Members of the public | 2 | 100% |
Mendeley readers
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Unknown | 20 | 100% |
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Researcher | 3 | 15% |
Other | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Professor > Associate Professor | 2 | 10% |
Student > Master | 2 | 10% |
Other | 4 | 20% |
Unknown | 3 | 15% |
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Linguistics | 1 | 5% |
Unspecified | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Computer Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 3 | 15% |