Title |
LFCseq: a nonparametric approach for differential expression analysis of RNA-seq data
|
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Published in |
BMC Genomics, December 2014
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DOI | 10.1186/1471-2164-15-s10-s7 |
Pubmed ID | |
Authors |
Bingqing Lin, Li-Feng Zhang, Xin Chen |
Abstract |
With the advances in high-throughput DNA sequencing technologies, RNA-seq has rapidly emerged as a powerful tool for the quantitative analysis of gene expression and transcript variant discovery. In comparative experiments, differential expression analysis is commonly performed on RNA-seq data to identify genes/features that are differentially expressed between biological conditions. Most existing statistical methods for differential expression analysis are parametric and assume either Poisson distribution or negative binomial distribution on gene read counts. However, violation of distributional assumptions or a poor estimation of parameters often leads to unreliable results. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 2 | 40% |
France | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 5% |
Ireland | 1 | 3% |
Italy | 1 | 3% |
Brazil | 1 | 3% |
New Zealand | 1 | 3% |
Russia | 1 | 3% |
United States | 1 | 3% |
Unknown | 32 | 80% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 28% |
Student > Ph. D. Student | 9 | 23% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Professor > Associate Professor | 4 | 10% |
Other | 2 | 5% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 57% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Computer Science | 2 | 5% |
Mathematics | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 2 | 5% |
Unknown | 5 | 13% |