Title |
Viral Vectors Encoding Endomorphins and Serine Histogranin Attenuate Neuropathic Pain Symptoms after Spinal Cord Injury in Rats
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Published in |
Molecular Pain, January 2015
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DOI | 10.1186/1744-8069-11-2 |
Pubmed ID | |
Authors |
Farinaz Nasirinezhad, Shyam Gajavelli, Blake Priddy, Stanislava Jergova, James Zadina, Jacqueline Sagen |
Abstract |
The treatment of spinal cord injury (SCI)-induced neuropathic pain presents a challenging healthcare problem. The lack of available robust pharmacological treatments underscores the need for novel therapeutic methods and approaches. Due to the complex character of neuropathic pain following SCI, therapies targeting multiple mechanisms may be a better choice for obtaining sufficient long-term pain relief. Previous studies in our lab showed analgesic effects using combinations of an NMDA antagonist peptide [Ser1]histogranin (SHG), and the mu-opioid peptides endomorphins (EMs), in several pain models. As an alternative to drug therapy, this study evaluated the analgesic potential of these peptides when delivered via gene therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 25% |
India | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 18% |
Researcher | 6 | 15% |
Student > Master | 5 | 13% |
Student > Ph. D. Student | 4 | 10% |
Professor > Associate Professor | 3 | 8% |
Other | 7 | 18% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
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Neuroscience | 8 | 20% |
Agricultural and Biological Sciences | 6 | 15% |
Engineering | 3 | 8% |
Unspecified | 2 | 5% |
Other | 4 | 10% |
Unknown | 8 | 20% |