Title |
Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes
|
---|---|
Published in |
Lipids in Health and Disease, July 2010
|
DOI | 10.1186/1476-511x-9-75 |
Pubmed ID | |
Authors |
Karima Bencharif, Laurence Hoareau, Ravi K Murumalla, Evelyne Tarnus, Frank Tallet, Roger G Clerc, Christophe Gardes, Maya Cesari, Régis Roche |
Abstract |
The risk of cardiovascular disease is inversely correlated to level of plasma HDL-c. Moreover, reverse cholesterol transport (RCT) from peripheral tissues to the liver is the most widely accepted mechanism linked to the anti-atherosclerotic activity of HDL. The apolipoprotein A-I (apoA-I) and the ABC transporters play a key role in this process.Adipose tissue constitutes the body's largest pool of free cholesterol. The adipose cell could therefore be regarded as a key factor in cholesterol homeostasis. The present study investigates the capacity of primary cultures of mature human adipocytes to release cholesterol and explores the relationships between apoA-I, ABCA1, and apoE as well as the signaling pathways that could be potentially involved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Luxembourg | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 33 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 26% |
Student > Ph. D. Student | 6 | 17% |
Other | 4 | 11% |
Student > Bachelor | 3 | 9% |
Student > Master | 3 | 9% |
Other | 6 | 17% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 34% |
Medicine and Dentistry | 7 | 20% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Neuroscience | 2 | 6% |
Other | 1 | 3% |
Unknown | 6 | 17% |