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Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes

Overview of attention for article published in Lipids in Health and Disease, July 2010
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Title
Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes
Published in
Lipids in Health and Disease, July 2010
DOI 10.1186/1476-511x-9-75
Pubmed ID
Authors

Karima Bencharif, Laurence Hoareau, Ravi K Murumalla, Evelyne Tarnus, Frank Tallet, Roger G Clerc, Christophe Gardes, Maya Cesari, Régis Roche

Abstract

The risk of cardiovascular disease is inversely correlated to level of plasma HDL-c. Moreover, reverse cholesterol transport (RCT) from peripheral tissues to the liver is the most widely accepted mechanism linked to the anti-atherosclerotic activity of HDL. The apolipoprotein A-I (apoA-I) and the ABC transporters play a key role in this process.Adipose tissue constitutes the body's largest pool of free cholesterol. The adipose cell could therefore be regarded as a key factor in cholesterol homeostasis. The present study investigates the capacity of primary cultures of mature human adipocytes to release cholesterol and explores the relationships between apoA-I, ABCA1, and apoE as well as the signaling pathways that could be potentially involved.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 3%
Brazil 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Ph. D. Student 6 17%
Other 4 11%
Student > Bachelor 3 9%
Student > Master 3 9%
Other 6 17%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 34%
Medicine and Dentistry 7 20%
Biochemistry, Genetics and Molecular Biology 5 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Neuroscience 2 6%
Other 1 3%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2015.
All research outputs
#18,388,295
of 22,776,824 outputs
Outputs from Lipids in Health and Disease
#983
of 1,443 outputs
Outputs of similar age
#84,937
of 94,579 outputs
Outputs of similar age from Lipids in Health and Disease
#9
of 11 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,443 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,579 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.