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Attention Score in Context
| Title |
Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip
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|---|---|
| Published in |
Arthritis Research & Therapy, January 2015
|
| DOI | 10.1186/s13075-014-0513-1 |
| Pubmed ID | |
| Authors |
Hui Wang, Xiang Zhang, Ji-Ye He, Xin-Feng Zheng, De Li, Zheng Li, Jun-Feng Zhu, Chao Shen, Gui-Quan Cai, Xiao-Dong Chen |
| Abstract |
IntroductionDevelopmental dysplasia of the hip (DDH) is a common musculoskeletal disorder with pain and loss of joint function as major pathological features. The present study explored the mechanisms of possible involvement and regulation of neuropeptides: substance P (SP) and calcitonin gene-related peptide (CGRP) in the pathological and inflammatory process of arthritis in DDH.MethodsBlood, synovial tissue and fluid samples were collected from patients diagnosed with varied severities of DDH and patients with femoral neck fracture. Levels of SP, CGRP and inflammatory cytokines in synovium and synovial fluid (SF) among different groups were evaluated with immunohistochemistry (IHC), real-time polymerase chain reaction (PCR) and Enzyme-linked immunosorbent assay (ELISA). Correlations between neuropeptides and inflammatory cytokines in SF were evaluated by partial correlation analysis. The pro-inflammatory effects of SP and CGRP on synoviocytes from moderate DDH in vitro were investigated by real-time PCR and ELISA. The mechanisms of those effects were analyzed by Western-blot and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-¿B) DNA binding assay.ResultsSignificantly increased levels of neuropeptides and inflammatory cytokines were observed in synovium and synovial fluid from patients in the severe DDH group compared with the moderate DDH group and control group. In moderate DDH cases, SP in SF correlated with tumor necrosis factor (TNF)-¿ and CGRP in SF correlated with TNF-¿ and interleukin (IL)-10. In severe DDH cases, SP in SF correlated with IL-1ß, TNF-¿ and IL-10. CGRP in SF correlated with TNF-¿. Additionally, SP might have obvious pro-inflammatory effects on synoviocytes through the activation of NF-¿B.ConclusionsThe up-regulation of SP and CGRP in synovium and synovial fluid might participate in the inflammatory progress of arthritis in DDH. The activation of the NF-¿B pathway seems indispensible in the pro-inflammatory effect of SP on synoviocytes. This original discovery probably indicates potential clinical drug target and innovative therapies for DDH treatment. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Germany | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 17% |
| Researcher | 5 | 12% |
| Student > Ph. D. Student | 5 | 12% |
| Professor > Associate Professor | 4 | 10% |
| Student > Doctoral Student | 2 | 5% |
| Other | 8 | 20% |
| Unknown | 10 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 32% |
| Agricultural and Biological Sciences | 5 | 12% |
| Chemistry | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Social Sciences | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 9 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2015.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#2,814
of 3,381 outputs
Outputs of similar age
#252,893
of 359,790 outputs
Outputs of similar age from Arthritis Research & Therapy
#42
of 48 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,790 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.