Title |
Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study
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Published in |
BMC Pregnancy and Childbirth, February 2010
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DOI | 10.1186/1471-2393-10-8 |
Pubmed ID | |
Authors |
Joepe J Kaandorp, Manon JNL Benders, Carin MA Rademaker, Helen L Torrance, Martijn A Oudijk, Timo R de Haan, Kitty WM Bloemenkamp, Monique Rijken, Maria G van Pampus, Arie F Bos, Martina M Porath, Sidarto Bambang Oetomo, Christine Willekes, AW Danilo Gavilanes, Maurice GAJ Wouters, Ruurd M van Elburg, Anjoke JM Huisjes, Saskia CMJER Bakker, Claudia A van Meir, Jeannette von Lindern, Janine Boon, Inge P de Boer, Robbert JP Rijnders, Corrie JWFM Jacobs, Cuno SPM Uiterwaal, Ben Willem J Mol, Gerard HA Visser, Frank van Bel, Jan B Derks |
Abstract |
Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. The xanthine-oxidase inhibitor allopurinol reduces the formation of free radicals, thereby limiting the amount of hypoxia-reperfusion damage. In case of suspected intra-uterine hypoxia, both animal and human studies suggest that maternal administration of allopurinol immediately prior to delivery reduces hypoxic-ischaemic encephalopathy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
Peru | 1 | <1% |
Spain | 1 | <1% |
Unknown | 129 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 19% |
Student > Ph. D. Student | 20 | 15% |
Researcher | 17 | 12% |
Student > Bachelor | 12 | 9% |
Professor | 9 | 7% |
Other | 31 | 23% |
Unknown | 22 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 52 | 38% |
Psychology | 15 | 11% |
Nursing and Health Professions | 14 | 10% |
Agricultural and Biological Sciences | 7 | 5% |
Neuroscience | 7 | 5% |
Other | 16 | 12% |
Unknown | 26 | 19% |