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The immune modifying effects of amino acids on gut-associated lymphoid tissue

Overview of attention for article published in Journal of Animal Science and Biotechnology, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#41 of 686)
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
11 tweeters
video
1 video uploader

Citations

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119 Dimensions

Readers on

mendeley
193 Mendeley
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Title
The immune modifying effects of amino acids on gut-associated lymphoid tissue
Published in
Journal of Animal Science and Biotechnology, July 2013
DOI 10.1186/2049-1891-4-27
Pubmed ID
Authors

Megan R Ruth, Catherine J Field

Abstract

The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system is well established. Less is known regarding the immune modifying properties of individual amino acids, particularly on the GALT. Both oral and parenteral feeding studies have established convincing evidence that not only the total protein intake, but the availability of specific dietary amino acids (in particular glutamine, glutamate, and arginine, and perhaps methionine, cysteine and threonine) are essential to optimizing the immune functions of the intestine and the proximal resident immune cells. These amino acids each have unique properties that include, maintaining the integrity, growth and function of the intestine, as well as normalizing inflammatory cytokine secretion and improving T-lymphocyte numbers, specific T cell functions, and the secretion of IgA by lamina propria cells. Our understanding of this area has come from studies that have supplemented single amino acids to a mixed protein diet and measuring the effect on specific immune parameters. Future studies should be designed using amino acid mixtures that target a number of specific functions of GALT in order to optimize immune function in domestic animals and humans during critical periods of development and various disease states.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Denmark 1 <1%
Unknown 191 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 36 19%
Student > Master 31 16%
Researcher 28 15%
Student > Ph. D. Student 25 13%
Student > Postgraduate 9 5%
Other 34 18%
Unknown 30 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 59 31%
Medicine and Dentistry 36 19%
Biochemistry, Genetics and Molecular Biology 19 10%
Nursing and Health Professions 10 5%
Immunology and Microbiology 6 3%
Other 21 11%
Unknown 42 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2022.
All research outputs
#3,413,778
of 21,885,643 outputs
Outputs from Journal of Animal Science and Biotechnology
#41
of 686 outputs
Outputs of similar age
#51,894
of 345,893 outputs
Outputs of similar age from Journal of Animal Science and Biotechnology
#2
of 23 outputs
Altmetric has tracked 21,885,643 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 686 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.