Title |
Mitochondrial reactive oxygen species and cancer
|
---|---|
Published in |
Cancer & Metabolism, November 2014
|
DOI | 10.1186/2049-3002-2-17 |
Pubmed ID | |
Authors |
Lucas B Sullivan, Navdeep S Chandel |
Abstract |
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent paradigm shift has shown that mROS can act as signaling molecules to activate pro-growth responses. Cancer cells have long been observed to have increased production of ROS relative to normal cells, although the implications of this increase were not always clear. This is especially interesting considering cancer cells often also induce expression of antioxidant proteins. Here, we discuss how cancer-associated mutations and microenvironments can increase production of mROS, which can lead to activation of tumorigenic signaling and metabolic reprogramming. This tumorigenic signaling also increases expression of antioxidant proteins to balance the high production of ROS to maintain redox homeostasis. We also discuss how cancer-specific modifications to ROS and antioxidants may be targeted for therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | <1% |
United States | 3 | <1% |
Japan | 3 | <1% |
Spain | 2 | <1% |
Denmark | 1 | <1% |
Mauritius | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 639 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 125 | 19% |
Researcher | 88 | 13% |
Student > Bachelor | 81 | 12% |
Student > Master | 73 | 11% |
Student > Doctoral Student | 36 | 5% |
Other | 86 | 13% |
Unknown | 166 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 162 | 25% |
Agricultural and Biological Sciences | 110 | 17% |
Medicine and Dentistry | 57 | 9% |
Chemistry | 37 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 24 | 4% |
Other | 70 | 11% |
Unknown | 195 | 30% |