Title |
Production of C2–C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies
|
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Published in |
Biotechnology for Biofuels and Bioproducts, December 2017
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DOI | 10.1186/s13068-017-0992-9 |
Pubmed ID | |
Authors |
Ye Zhang, Dehua Liu, Zhen Chen |
Abstract |
C2-C4 diols classically derived from fossil resource are very important bulk chemicals which have been used in a wide range of areas, including solvents, fuels, polymers, cosmetics, and pharmaceuticals. Production of C2-C4 diols from renewable resources has received significant interest in consideration of the reducing fossil resource and the increasing environmental issues. While bioproduction of certain diols like 1,3-propanediol has been commercialized in recent years, biosynthesis of many other important C2-C4 diol isomers is highly challenging due to the lack of natural synthesis pathways. Recent advances in synthetic biology have enabled the de novo design of completely new pathways to non-natural molecules from renewable feedstocks. In this study, we review recent advances in bioproduction of C2-C4 diols, focusing on new metabolic pathways and metabolic engineering strategies being developed. We also discuss the challenges and future trends toward the development of economically competitive processes for bio-based diol production. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 7 | 78% |
Ireland | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 89% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 132 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 21% |
Researcher | 27 | 20% |
Student > Master | 14 | 11% |
Student > Bachelor | 11 | 8% |
Student > Doctoral Student | 5 | 4% |
Other | 10 | 8% |
Unknown | 37 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 26 | 20% |
Agricultural and Biological Sciences | 19 | 14% |
Chemical Engineering | 17 | 13% |
Chemistry | 13 | 10% |
Engineering | 6 | 5% |
Other | 9 | 7% |
Unknown | 42 | 32% |