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Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats

Overview of attention for article published in The Journal of Physiological Sciences, March 2014
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Title
Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats
Published in
The Journal of Physiological Sciences, March 2014
DOI 10.1007/s12576-014-0312-0
Pubmed ID
Authors

Yuri Nishimura, Kaori Mabuchi, Sayumi Taguchi, Saori Ikeda, Eri Aida, Hiroko Negishi, Akira Takamata

Abstract

In order to elucidate the involvement of melanin-concentrating hormone (MCH) and orexin-A (ORX-A) neurons of the perifornical/lateral hypothalamic areas (PF/LH) in the regulation of food intake induced by acutely reduced glucose availability, we examined the food intake response and c-Fos expression in the MCH and ORX-A neurons in the PF/LH during 2-deoxy-D-glucose (2DG)-induced glucoprivation (400 mg/kg; i.v.) and systemic insulin-induced hypoglycemia (5 U/kg; s.c.) in male Wistar rats. The administration of both 2DG and insulin stimulated food intake and induced c-Fos expression in the ORX-A neurons corresponding to food intake, but not in the MCH neurons. These data indicate that ORX-A neurons, but not MCH neurons, play a role in the short-term regulation of food intake, and that the input signals for the neurons containing MCH and ORX-A are different, and these neurons play different roles in the regulation of feeding behavior.

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 8%
Poland 1 4%
United States 1 4%
Unknown 21 84%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Student > Doctoral Student 4 16%
Student > Master 4 16%
Student > Bachelor 2 8%
Professor > Associate Professor 2 8%
Other 3 12%
Unknown 2 8%
Readers by discipline Count As %
Neuroscience 9 36%
Agricultural and Biological Sciences 7 28%
Medicine and Dentistry 2 8%
Business, Management and Accounting 1 4%
Social Sciences 1 4%
Other 3 12%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2015.
All research outputs
#21,476,880
of 23,975,976 outputs
Outputs from The Journal of Physiological Sciences
#267
of 321 outputs
Outputs of similar age
#198,487
of 228,463 outputs
Outputs of similar age from The Journal of Physiological Sciences
#5
of 5 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 321 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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