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Outer membrane protein folding from an energy landscape perspective

Overview of attention for article published in BMC Biology, December 2017
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Title
Outer membrane protein folding from an energy landscape perspective
Published in
BMC Biology, December 2017
DOI 10.1186/s12915-017-0464-5
Pubmed ID
Authors

Bob Schiffrin, David J. Brockwell, Sheena E. Radford

Abstract

The cell envelope is essential for the survival of Gram-negative bacteria. This specialised membrane is densely packed with outer membrane proteins (OMPs), which perform a variety of functions. How OMPs fold into this crowded environment remains an open question. Here, we review current knowledge about OMP folding mechanisms in vitro and discuss how the need to fold to a stable native state has shaped their folding energy landscapes. We also highlight the role of chaperones and the β-barrel assembly machinery (BAM) in assisting OMP folding in vivo and discuss proposed mechanisms by which this fascinating machinery may catalyse OMP folding.

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The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 133 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 28%
Student > Bachelor 15 11%
Researcher 13 10%
Student > Master 9 7%
Student > Doctoral Student 9 7%
Other 18 14%
Unknown 32 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 53 40%
Agricultural and Biological Sciences 19 14%
Chemistry 6 5%
Immunology and Microbiology 4 3%
Physics and Astronomy 4 3%
Other 14 11%
Unknown 33 25%