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Mendeley readers
Attention Score in Context
| Title |
High dose intravenous colistin methanesulfonate therapy is associated with high rates of nephrotoxicity; a prospective cohort study from Saudi Arabia
|
|---|---|
| Published in |
Annals of Clinical Microbiology and Antimicrobials, January 2015
|
| DOI | 10.1186/s12941-015-0062-8 |
| Pubmed ID | |
| Authors |
Ali S Omrani, Wafa A Alfahad, Mohamed M Shoukri, Abeer M Baadani, Sultan Aldalbahi, Ali A Almitwazi, Ali M Albarrak |
| Abstract |
BackgroundNephrotoxicity is an important adverse effect of colistin methanesulfonate (CMS) therapy. No data exist on rates and risk factors for colistin-related nephrotoxicity in Saudi Arabia (SA). We conducted a prospective cohort study to identify rates and risk factors for CMS nephrotoxicity in our patient population.MethodsWe prospectively included adult patients who received ¿48 hours of intravenous CMS therapy. Pregnant patients and those on renal replacement were excluded. Patients received 9 million units (mU) loading dose followed by 3 mU 8 hourly. In renal impairment, CMS dosing was adjusted according to calculated creatinine clearance (CrCl). Nephrotoxicity was defined as per RIFLE criteria (Risk, Injury, Failure, Loss and End-stage renal disease). Statistical analysis was performed using SPSS version 20.0 (IBM, Armonk, New York, USA). The study was approved by the institution¿s Research Ethics Committee.ResultsA total of 67 patients were included in the study. Mean (±standard deviation) age was 57.5 (±24.0) years, Charlson Co-morbidity Score 2.88 (±2.39), CrCl 133.60 (±92.54) mL/min and serum albumin 28.65 (±4.45) g/L. Mean CMS dose was 0.11 (±0.04) mU/kg/day and mean total CMS dose received was 101.21 (±47.37) mU. Fifty-one (76.1%) patients developed RIFLE-defined nephrotoxicity. Mean total CMS dose and duration of therapy before onset of nephrotoxicity were 66.71 (±43.45) mU and 8.70 (±6.70) days, respectively. In bivariate analysis, patients with nephrotoxicity were significantly older (P 0.013) and had lower baseline serum albumin (P 0.008). Multivariate logistic regression identified serum albumin [odds ratio (OR) 0.72; 95% confidence interval (CI) 0.57¿0.93; P 0.010] and intensive care admission (OR 16.38; 95% CI 1.37¿195.55; P 0.027) as independent risk factors for CMS nephrotoxicity.ConclusionsHigh dose intravenous CMS therapy is associated with high rates of nephrotoxicity in SA. Independent risk factors for colistin nephrotoxicity were baseline hypoalbuminemia and intensive care admission. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 3 | 25% |
| Unknown | 9 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 61 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 13% |
| Other | 7 | 11% |
| Researcher | 6 | 10% |
| Student > Master | 6 | 10% |
| Student > Postgraduate | 5 | 8% |
| Other | 15 | 24% |
| Unknown | 15 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 34% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
| Psychology | 3 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 20 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2021.
All research outputs
#4,160,043
of 25,728,855 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#80
of 682 outputs
Outputs of similar age
#54,545
of 361,984 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#2
of 9 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 682 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,984 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.