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Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study

Overview of attention for article published in Arthritis Research & Therapy, December 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
1 news outlet
twitter
13 tweeters
facebook
2 Facebook pages

Citations

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22 Dimensions

Readers on

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52 Mendeley
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Title
Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Published in
Arthritis Research & Therapy, December 2017
DOI 10.1186/s13075-017-1494-7
Pubmed ID
Authors

Silje Reiseter, Ragnar Gunnarsson, Jukka Corander, Joanna Haydon, May Brit Lund, Trond Mogens Aaløkken, Eli Taraldsrud, Siri Opsahl Hetlevik, Øyvind Molberg

Abstract

The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution from MCTD to another defined rheumatic condition, and the prevalence and durability of remission after long-term observation. In this large population-based prospective observational MCTD cohort study (N = 118), disease conversion was defined by the development of new auto-antibodies and clinical features compliant with another well-defined rheumatic condition. Remission was defined by a combination of systemic lupus erythematosus disease activity index 2000 (SLEDAI-2 K) of 0 and European League Against Rheumatism scleroderma trials and research (EUSTAR) activity index <2.5. Predictors of phenotypic stability and disease remission were assessed by logistic regression. Among 118 patients, 14 (12%) developed another well-defined rheumatic condition other than MCTD after mean disease duration of 17 (SD 9) years. Puffy hands predicted a stable MCTD phenotype in univariable regression analysis (OR 7, CI 2-27, P = .010). Disease activity defined by SLEDAI-2 K, decreased gradually across the observation period and > 90% of patients had EUSTAR activity index <2.5. There were 13% patients in remission throughout the whole mean observation period of 7 (SD 2) years. The strongest predictor of remission was percentage of predicted higher forced vital capacity. Our results strengthen the view of MCTD as a relatively stable disease entity. Long-term remission in MCTD is not frequent; however, the low SLEDAI-2 K and EUSTAR scores during the observation period suggests that the disease runs a milder course than systemic lupus erythematosus and systemic sclerosis.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 8 15%
Researcher 7 13%
Other 4 8%
Student > Ph. D. Student 4 8%
Student > Bachelor 3 6%
Other 8 15%
Unknown 18 35%
Readers by discipline Count As %
Medicine and Dentistry 20 38%
Engineering 3 6%
Agricultural and Biological Sciences 2 4%
Business, Management and Accounting 1 2%
Economics, Econometrics and Finance 1 2%
Other 3 6%
Unknown 22 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2019.
All research outputs
#1,498,848
of 19,304,528 outputs
Outputs from Arthritis Research & Therapy
#287
of 2,732 outputs
Outputs of similar age
#46,782
of 426,880 outputs
Outputs of similar age from Arthritis Research & Therapy
#22
of 209 outputs
Altmetric has tracked 19,304,528 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,732 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 426,880 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 209 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.