You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The number of circulating monocytes as biomarkers of the clinical response to methotrexate in untreated patients with rheumatoid arthritis
|
|---|---|
| Published in |
Journal of Translational Medicine, January 2015
|
| DOI | 10.1186/s12967-014-0375-y |
| Pubmed ID | |
| Authors |
Luis Chara, Ana Sánchez-Atrio, Ana Pérez, Eduardo Cuende, Fernando Albarrán, Ana Turrión, Julio Chevarria, Angel Asunsolo del Barco, Miguel A Sánchez, Jorge Monserrat, Alfredo Prieto, Antonio de la Hera, Ignacio Sanz, David Diaz, Melchor Alvarez-Mon |
| Abstract |
BackgroundThe aim of this work was to analyze the number and distribution of circulating monocytes, and of their CD14+highCD16¿, CD14+highCD16+ and CD14+lowCD16+ subset cells, in treatment-naive patients with rheumatoid arthritis (RA), and to determine their value in predicting the clinical response to methotrexate (MTX) treatment.MethodsThis prospective work investigated the number of circulating monocytes, and the numbers of CD14+highCD16¿, CD14+highCD16+ and CD14+lowCD16+ subset cells, in 52 untreated patients with RA before MTX treatment, and at 3 and 6 months into treatment, using flow cytometry.ResultsThe absolute number of circulating monocytes, and the numbers of CD14+highCD16¿, CD14+highCD16+ and CD14+lowCD16+ subset cells, were significantly higher in MTX non-responders than in responders and healthy controls before starting and throughout treatment. Responders showed normal numbers of monocytes, and of their subset cells, over the study period. The pre-treatment absolute number of circulating monocytes, and the numbers of CD14+highCD16¿ and CD14+highCD16+ subset cells, were found to be predictive of the clinical response to MTX, with a sensitivity and specificity of >70% and >88%, respectively.ConclusionsTreatment-naive patients with RA showed an anomalous distribution of circulating monocyte subsets, and an anomalous number of cells in each subset. A higher pre-treatment number of circulating monocytes, and higher numbers of CD14+highCD16¿ and CD14+highCD16+ subset cells, predict a reduced clinical response to MTX in untreated patients with RA. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 20% |
| Researcher | 11 | 18% |
| Other | 6 | 10% |
| Student > Postgraduate | 4 | 7% |
| Student > Master | 4 | 7% |
| Other | 14 | 23% |
| Unknown | 9 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 25% |
| Immunology and Microbiology | 8 | 13% |
| Agricultural and Biological Sciences | 7 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 12 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#13,321,085
of 22,778,347 outputs
Outputs from Journal of Translational Medicine
#1,575
of 3,987 outputs
Outputs of similar age
#171,330
of 352,360 outputs
Outputs of similar age from Journal of Translational Medicine
#49
of 127 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,987 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.