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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells
|
|---|---|
| Published in |
Stem Cell Research & Therapy, December 2017
|
| DOI | 10.1186/s13287-017-0742-8 |
| Pubmed ID | |
| Authors |
Alix K. Berglund, Lisa A. Fortier, Douglas F. Antczak, Lauren V. Schnabel |
| Abstract |
Autologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. Allogeneic MSCs are especially attractive due to their potential to provide immediate care at the time of tissue injury or disease diagnosis. The prevailing dogma has been that allogeneic MSCs are immune privileged, but there have been very few studies that control for matched or mismatched major histocompatibility complex (MHC) molecule expression and that examine immunogenicity in vivo. Studies that control for MHC expression have reported both cell-mediated and humoral immune responses to MHC-mismatched MSCs. The clinical implications of immune responses to MHC-mismatched MSCs are still unknown. Pre-clinical and clinical studies that document the MHC haplotype of donors and recipients and measure immune responses following MSC treatment are necessary to answer this critical question. This review details what is currently known about the immunogenicity of allogeneic MSCs and suggests contemporary assays that could be utilized in future studies to appropriately identify and measure immune responses to MHC-mismatched MSCs. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| New Zealand | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 234 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 16% |
| Student > Ph. D. Student | 36 | 15% |
| Student > Master | 24 | 10% |
| Student > Bachelor | 23 | 10% |
| Other | 12 | 5% |
| Other | 28 | 12% |
| Unknown | 73 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 15% |
| Medicine and Dentistry | 35 | 15% |
| Agricultural and Biological Sciences | 23 | 10% |
| Immunology and Microbiology | 17 | 7% |
| Veterinary Science and Veterinary Medicine | 13 | 6% |
| Other | 26 | 11% |
| Unknown | 85 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2023.
All research outputs
#5,326,693
of 25,257,066 outputs
Outputs from Stem Cell Research & Therapy
#568
of 2,738 outputs
Outputs of similar age
#106,639
of 454,178 outputs
Outputs of similar age from Stem Cell Research & Therapy
#13
of 62 outputs
Altmetric has tracked 25,257,066 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,738 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.