Title |
Clinical implementation of whole-genome array CGH as a first-tier test in 5080 pre and postnatal cases
|
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Published in |
Molecular Cytogenetics, May 2011
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DOI | 10.1186/1755-8166-4-12 |
Pubmed ID | |
Authors |
Sang-Jin Park, Eun Hye Jung, Ran-Suk Ryu, Hyun Woong Kang, Jung-Min Ko, Hyon J Kim, Chong Kun Cheon, Sang-Hyun Hwang, Ho-Young Kang |
Abstract |
Array comparative genomic hybridization (CGH) is currently the most powerful method for detecting chromosomal alterations in pre and postnatal clinical cases. In this study, we developed a BAC based array CGH analysis platform for detecting whole genome DNA copy number changes including specific micro deletion and duplication chromosomal disorders. Additionally, we report our experience with the clinical implementation of our array CGH analysis platform. Array CGH was performed on 5080 pre and postnatal clinical samples from patients referred with a variety of clinical phenotypes. |
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