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Local uterine Ang-(1–7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats

Overview of attention for article published in Reproductive Biology and Endocrinology, January 2015
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Title
Local uterine Ang-(1–7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats
Published in
Reproductive Biology and Endocrinology, January 2015
DOI 10.1186/1477-7827-13-5
Pubmed ID
Authors

K Bridget Brosnihan, Victor M Pulgar, Patricia E Gallagher, Liomar AA Neves, Liliya M Yamaleyeva

Abstract

Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantation site (IS) in normal pregnancy at day 7 of gestation. We determined the effects of intra-uterine angiotensin-(1-7) [Ang-(1-7)] (24 microg/kg/h) or vehicle given into the left uterine horn on the ECs in the decidualized uterus.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 14%
Student > Ph. D. Student 3 14%
Researcher 3 14%
Lecturer 2 10%
Student > Postgraduate 2 10%
Other 3 14%
Unknown 5 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Engineering 2 10%
Nursing and Health Professions 1 5%
Other 2 10%
Unknown 6 29%