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Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil

Overview of attention for article published in BMC Complementary Medicine and Therapies, December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 3,954)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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26 news outlets
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1 X user
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1 Facebook page

Citations

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34 Dimensions

Readers on

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103 Mendeley
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Title
Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil
Published in
BMC Complementary Medicine and Therapies, December 2017
DOI 10.1186/s12906-017-2060-1
Pubmed ID
Authors

Myra O. Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati, Hiroko Isoda

Abstract

Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential oils (EOs) an attractive alternative therapy. Rosmarinus officinalis EO (ROEO), Mediterranean ROEO reported to improve cognition, mood, and memory, the effect on stress of which has not yet been determined. Here, the anti-stress effect of ROEO on stress was evaluated in vivo and in vitro. Six-week-old male ICR mice were made to inhale ROEO and subjected to tail suspension test (TST). To determine the neuronal differentiation effect of ROEO in vitro, induction of ROEO-treated PC12 cells differentiation was observed. Intracellular acetylcholine and choline, as well as the Gap43 gene expression levels were also determined. Inhalation of ROEO significantly decreased the immobility time of ICR mice and serum corticosterone level, accompanied by increased brain dopamine level. Determination of the underlying mechanism in vitro revealed a PC12 differentiation-induction effect through the modulation of intracellular acetylcholine, choline, and Gap43 gene expression levels. ROEO activates the stress response system through the NGF pathway and the hypothalamus-pituitary-adrenal axis, promoting dopamine production and secretion. The effect of ROEO may be attributed to its bioactive components, specifically to α-pinene, one of its major compounds that has anxiolytic property. The results of this study suggest that ROEO inhalation has therapeutic potential against stress-related psychiatric disorders.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 103 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 15%
Student > Master 10 10%
Researcher 9 9%
Student > Ph. D. Student 8 8%
Student > Doctoral Student 5 5%
Other 13 13%
Unknown 43 42%
Readers by discipline Count As %
Medicine and Dentistry 13 13%
Pharmacology, Toxicology and Pharmaceutical Science 12 12%
Agricultural and Biological Sciences 8 8%
Biochemistry, Genetics and Molecular Biology 4 4%
Neuroscience 4 4%
Other 12 12%
Unknown 50 49%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 209. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2023.
All research outputs
#185,538
of 25,359,594 outputs
Outputs from BMC Complementary Medicine and Therapies
#34
of 3,954 outputs
Outputs of similar age
#4,167
of 454,896 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#2
of 113 outputs
Altmetric has tracked 25,359,594 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,954 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,896 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.