Title |
Chemerin and CMKLR1 expression in human arteries and periadventitial fat: a possible role for local chemerin in atherosclerosis?
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Published in |
BMC Cardiovascular Disorders, April 2014
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DOI | 10.1186/1471-2261-14-56 |
Pubmed ID | |
Authors |
Christos G Kostopoulos, Sofia G Spiroglou, John N Varakis, Efstratios Apostolakis, Helen H Papadaki |
Abstract |
Depending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose tissue function and metabolism, acting in autocrine, paracrine and endocrine manners. We investigated the protein expression of chemerin and its receptor, CMKLR1, in human aortas, coronary vessels and the respective periadventitial adipose tissue and correlated their expression with the presence of atherosclerosis. |
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