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Mendeley readers
Attention Score in Context
| Title |
Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates
|
|---|---|
| Published in |
Journal of Biomedical Science, December 2014
|
| DOI | 10.1186/s12929-014-0105-z |
| Pubmed ID | |
| Authors |
Ednildes de Almeida Olympio Rua, Marcella Leite Porto, Jean Pierre Louzada Ramos, Breno Valentim Nogueira, Silvana dos Santos Meyrelles, Elisardo Corral Vasquez, Thiago de Melo Costa Pereira |
| Abstract |
BackgroundAlthough cigarette smoke is known to be a complex mixture of over 4000 substances that can lead to damage through active or passive smoking, its mechanisms and biochemical consequences in pregnancy and neonates are not yet fully understood. Therefore, in the present study, we propose to study the impact of smoking during gestation on the viability of blood mononuclear cells (MNC) from umbilical cords of newborns to assess the degree of oxidative stress and cell viability. Moreover, we aim to investigate possible biochemical and morphological changes in the umbilical cord.MethodsAfter childbirth, the cord blood and the umbilical cord were immediately collected in public hospitals in Greater Vitoria, ES, Brazil. Flow cytometry was used to analyze the cord blood and biochemical and histological tests were used to analyze the umbilical cord.ResultsPregnant smokers had a reduction of MNC viability from the umbilical cord (10%), an increase in the production of reactive oxygen species (ROS) and an increase in cell apoptosis (~2-fold) compared to pregnant non-smokers. In the umbilical cord, it was observed an increase of advanced oxidation protein products - AOPP (~2.5-fold) and a loss of the typical architecture and disposition of endothelial cells from the umbilical artery.ConclusionsThese data suggest that maternal cigarette smoking during pregnancy (even in small amounts) may compromise the viability of MNC cells and damage the umbilical cord structure, possibly by excessive ROS bioavailability. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Student > Master | 12 | 13% |
| Student > Ph. D. Student | 11 | 12% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 7 | 7% |
| Other | 12 | 13% |
| Unknown | 26 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 17% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Nursing and Health Professions | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Agricultural and Biological Sciences | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 31 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2020.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from Journal of Biomedical Science
#656
of 1,101 outputs
Outputs of similar age
#194,091
of 359,541 outputs
Outputs of similar age from Journal of Biomedical Science
#4
of 10 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,541 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.