Title |
Long-term efficacy and tolerability of quetiapine in patients with schizophrenia who switched from other antipsychotics because of inadequate therapeutic response—a prospective open-label study
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Published in |
Annals of General Psychiatry, January 2015
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DOI | 10.1186/s12991-014-0039-6 |
Pubmed ID | |
Authors |
Naoki Hashimoto, Atsuhito Toyomaki, Minoru Honda, Satoru Miyano, Nobuyuki Nitta, Hiroyuki Sawayama, Yasufumi Sugawara, Keiichi Uemura, Noriko Tsukamoto, Tsukasa Koyama, Ichiro Kusumi |
Abstract |
While the frequency and importance of antipsychotic switching in patients with schizophrenia, there is insufficient evidence with regard to switching strategy. Quetiapine is one of the drugs of choice for switch because of its unique receptor profile. However, there were no data on the long-term clinical and neurocognitive effect of quetiapine in patients who had responded inadequately to prior antipsychotics. The purpose of this study is to examine the long-term efficacy and tolerability of quetiapine in patients with schizophrenia who switched from other antipsychotics because of inadequate therapeutic response. We hypothesized that quetiapine would show long-term effectiveness in broad symptom dimensions including negative and neurocognitive symptoms while having good tolerability. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Singapore | 1 | 2% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 18% |
Researcher | 9 | 18% |
Student > Ph. D. Student | 6 | 12% |
Other | 4 | 8% |
Student > Master | 4 | 8% |
Other | 8 | 16% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 11 | 22% |
Medicine and Dentistry | 11 | 22% |
Neuroscience | 3 | 6% |
Unspecified | 2 | 4% |
Business, Management and Accounting | 2 | 4% |
Other | 9 | 18% |
Unknown | 11 | 22% |