Title |
Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells
|
---|---|
Published in |
World Allergy Organization Journal, January 2015
|
DOI | 10.1186/s40413-014-0054-8 |
Pubmed ID | |
Authors |
Stefanie Gilles, Isabelle Beck, Stefan Lange, Johannes Ring, Heidrun Behrendt, Claudia Traidl-Hoffmann |
Abstract |
Pollen allergens are delivered to epithelial surfaces of the upper respiratory tract in conjunction with multiple endogenous adjuvants. We previously demonstrated pollen-mediated modulation of cytokine and chemokine production of dendritic cells, contributing to a Th2-dominated micromilieu. As T helper cell differentiation not only depends on dendritic cell-derived cytokines but also on cell-cell-contact mediated mechanisms, we studied the expression of notch ligands and myeloid differentiation primary response protein 88 (MyD88) in dendritic cells matured in the presence of aqueous birch pollen extracts and pollen-associated E1-phytoprostanes. |
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Scientists | 2 | 22% |
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Mendeley readers
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Student > Bachelor | 4 | 14% |
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