Title |
Clathrin expression in Trypanosoma cruzi
|
---|---|
Published in |
BMC Molecular and Cell Biology, June 2014
|
DOI | 10.1186/1471-2121-15-23 |
Pubmed ID | |
Authors |
Ligia Cristina Kalb, Yohana Camila Antunes Frederico, Cassiano Martin Batista, Iriane Eger, Stênio Perdigão Fragoso, Maurilio José Soares |
Abstract |
Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocytosis) and transport from the trans-Golgi network towards the endosomal system. Clathrin-mediated events are still poorly understood in the protozoan Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. In this study, clathrin heavy (TcCHC) and light (TcCLC) chain gene expression and protein localization were investigated in different developmental forms of T. cruzi (epimastigotes, trypomastigotes and amastigotes), using both polyclonal and monoclonal antibodies raised against T. cruzi recombinant proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 21% |
Student > Master | 9 | 21% |
Researcher | 4 | 9% |
Student > Doctoral Student | 4 | 9% |
Student > Bachelor | 4 | 9% |
Other | 8 | 19% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 49% |
Biochemistry, Genetics and Molecular Biology | 10 | 23% |
Unspecified | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Environmental Science | 1 | 2% |
Other | 1 | 2% |
Unknown | 6 | 14% |