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Attention Score in Context
| Title |
Stability of 3-bromotyrosine in serum and serum 3-bromotyrosine concentrations in dogs with gastrointestinal diseases
|
|---|---|
| Published in |
BMC Veterinary Research, January 2015
|
| DOI | 10.1186/s12917-015-0321-0 |
| Pubmed ID | |
| Authors |
Panpicha Sattasathuchana, Niels Grützner, Rosana Lopes, Blake C Guard, Jan S Suchodolski, Jörg M Steiner |
| Abstract |
Background3-Bromotyrosine (3-BrY) is a stable product of eosinophil peroxidase and may serve as a marker of eosinophil activation. A gas chromatography/mass spectrometry method to measure 3-BrY concentrations in serum from dogs has recently been established and analytically validated. The aims of this study were to determine the stability of 3-BrY in serum, to determine the association between peripheral eosinophil counts and the presence of an eosinophilic infiltrate in the gastrointestinal tract, and to compare serum 3-BrY concentrations in healthy dogs (n¿=¿52) and dogs with eosinophilic gastroenteritis (EGE; n¿=¿27), lymphocytic-plasmacytic enteritis (LPE; n¿=¿25), exocrine pancreatic insufficiency (EPI; n¿=¿26), or pancreatitis (n¿=¿25).ResultsSerum 3-BrY concentrations were stable for up to 8, 30, and 180 days at 4°C, ¿20°C, and ¿80°C, respectively. There was no significant association between peripheral eosinophil count and the presence of eosinophils in the GI tissues (P¿=¿0.1733). Serum 3-BrY concentrations were significantly higher in dogs with EGE (median [range]¿=¿5.04 [¿0.63-26.26] ¿mol/L), LPE (median [range]¿=¿3.60 [¿0.63-15.67] ¿mol/L), and pancreatitis (median [range]¿=¿1.49 [¿0.63-4.46] ¿mol/L) than in healthy control dogs (median [range]¿=¿¿0.63 [¿0.63-1.79] ¿mol/L; P¿<¿0.0001), whereas concentrations in dogs with EPI (median [range]¿=¿0.73 [¿0.63-4.59] ¿mol/L) were not different compared to healthy control dogs.ConclusionsThe present study revealed that 3-BrY concentrations were stable in serum when refrigerated and frozen. No relationship between peripheral eosinophil count and the presence of eosinophils infiltration in the GI tissues was found in this study. In addition, serum 3-BrY concentrations were increased in dogs with EGE, but also in dogs with LPE and pancreatitis. Further studies are needed to determine whether measurement of 3-BrY concentrations in serum may be useful to assess patients with suspected or confirmed EGE or LPE. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Student > Doctoral Student | 2 | 11% |
| Other | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Master | 2 | 11% |
| Other | 4 | 21% |
| Unknown | 3 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 6 | 32% |
| Medicine and Dentistry | 6 | 32% |
| Agricultural and Biological Sciences | 2 | 11% |
| Unknown | 5 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from BMC Veterinary Research
#2,610
of 3,298 outputs
Outputs of similar age
#307,565
of 359,720 outputs
Outputs of similar age from BMC Veterinary Research
#56
of 60 outputs
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So far Altmetric has tracked 3,298 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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