Title |
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, January 2015
|
DOI | 10.1186/s40425-014-0043-z |
Pubmed ID | |
Authors |
Weiqing Jing, Jill A Gershan, James Weber, Dominique Tlomak, Laura McOlash, Catherine Sabatos-Peyton, Bryon D Johnson |
Abstract |
Multiple myeloma is characterized by the presence of transformed neoplastic plasma cells in the bone marrow and is generally considered to be an incurable disease. Successful treatments will likely require multi-faceted approaches incorporating conventional drug therapies, immunotherapy and other novel treatments. Our lab previously showed that a combination of transient lymphodepletion (sublethal whole body irradiation) and PD-1/PD-L1 blockade generated anti-myeloma T cell reactivity capable of eliminating established disease. We hypothesized that blocking a combination of checkpoint receptors in the context of low-dose, lymphodepleting whole body radiation would boost anti-tumor immunity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 50% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Science communicators (journalists, bloggers, editors) | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | <1% |
Denmark | 1 | <1% |
France | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 132 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 44 | 32% |
Student > Ph. D. Student | 20 | 15% |
Other | 11 | 8% |
Student > Master | 11 | 8% |
Student > Doctoral Student | 9 | 7% |
Other | 21 | 15% |
Unknown | 20 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 24% |
Agricultural and Biological Sciences | 31 | 23% |
Biochemistry, Genetics and Molecular Biology | 23 | 17% |
Immunology and Microbiology | 14 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 7 | 5% |
Unknown | 26 | 19% |