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Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma

Overview of attention for article published in Journal for Immunotherapy of Cancer, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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6 X users
patent
33 patents
facebook
1 Facebook page

Citations

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95 Dimensions

Readers on

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136 Mendeley
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Title
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma
Published in
Journal for Immunotherapy of Cancer, January 2015
DOI 10.1186/s40425-014-0043-z
Pubmed ID
Authors

Weiqing Jing, Jill A Gershan, James Weber, Dominique Tlomak, Laura McOlash, Catherine Sabatos-Peyton, Bryon D Johnson

Abstract

Multiple myeloma is characterized by the presence of transformed neoplastic plasma cells in the bone marrow and is generally considered to be an incurable disease. Successful treatments will likely require multi-faceted approaches incorporating conventional drug therapies, immunotherapy and other novel treatments. Our lab previously showed that a combination of transient lymphodepletion (sublethal whole body irradiation) and PD-1/PD-L1 blockade generated anti-myeloma T cell reactivity capable of eliminating established disease. We hypothesized that blocking a combination of checkpoint receptors in the context of low-dose, lymphodepleting whole body radiation would boost anti-tumor immunity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 <1%
Denmark 1 <1%
France 1 <1%
Korea, Republic of 1 <1%
Unknown 132 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 44 32%
Student > Ph. D. Student 20 15%
Other 11 8%
Student > Master 11 8%
Student > Doctoral Student 9 7%
Other 21 15%
Unknown 20 15%
Readers by discipline Count As %
Medicine and Dentistry 32 24%
Agricultural and Biological Sciences 31 23%
Biochemistry, Genetics and Molecular Biology 23 17%
Immunology and Microbiology 14 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 7 5%
Unknown 26 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#2,745,915
of 25,374,917 outputs
Outputs from Journal for Immunotherapy of Cancer
#752
of 3,421 outputs
Outputs of similar age
#37,460
of 359,955 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#3
of 7 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.