Title |
Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation
|
---|---|
Published in |
Autoimmunity Highlights, December 2017
|
DOI | 10.1007/s13317-017-0101-x |
Pubmed ID | |
Authors |
Tohid Hassanalilou, Leila Khalili, Saeid Ghavamzadeh, Ali Shokri, Laleh Payahoo, Yaser Khaje Bishak |
Abstract |
Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative role in SLE etiology. This paper analyzes existing data from various studies to highlight the role of vitamin D deficiency in SLE occurrence and aggravation and the probable efficacy of vitamin D supplementation on SLE patients. We searched "Science Direct" and "Pub Med" using "Vitamin D" and "SLE" for finding the studies focusing on the association between vitamin D deficiency and SLE incidence and consequences. Evidences show that vitamin D plays an important role in the pathogenesis and progression of SLE and vitamin D supplementation seems to ameliorate inflammatory and hemostatic markers; so, can improve clinical subsequent. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 34% |
United Kingdom | 3 | 10% |
Belgium | 1 | 3% |
Nigeria | 1 | 3% |
Unknown | 14 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 76% |
Practitioners (doctors, other healthcare professionals) | 4 | 14% |
Scientists | 2 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 174 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 29 | 17% |
Student > Master | 24 | 14% |
Other | 10 | 6% |
Researcher | 9 | 5% |
Student > Doctoral Student | 7 | 4% |
Other | 21 | 12% |
Unknown | 74 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 58 | 33% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Nursing and Health Professions | 8 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Immunology and Microbiology | 4 | 2% |
Other | 14 | 8% |
Unknown | 77 | 44% |