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Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines

Overview of attention for article published in Cancer Cell International, January 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
105 Dimensions

Readers on

mendeley
100 Mendeley
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Title
Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
Published in
Cancer Cell International, January 2006
DOI 10.1186/1475-2867-6-2
Pubmed ID
Authors

Alma Chavez-Blanco, Carlos Perez-Plasencia, Enrique Perez-Cardenas, Claudia Carrasco-Legleu, Edgar Rangel-Lopez, Blanca Segura-Pacheco, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Myrna Candelaria, Gustavo Cabrera, Alfonso Duenas-Gonzalez

Abstract

Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of experimental models. The objective of this study was to evaluate the combined antineoplastic effect of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in a panel of cancer cell lines.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 100 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 17%
Student > Ph. D. Student 16 16%
Student > Master 15 15%
Student > Bachelor 15 15%
Professor 5 5%
Other 20 20%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 30%
Medicine and Dentistry 25 25%
Biochemistry, Genetics and Molecular Biology 13 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Neuroscience 4 4%
Other 8 8%
Unknown 15 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#5,343,036
of 25,059,640 outputs
Outputs from Cancer Cell International
#832
of 2,142 outputs
Outputs of similar age
#21,715
of 167,001 outputs
Outputs of similar age from Cancer Cell International
#1
of 4 outputs
Altmetric has tracked 25,059,640 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,142 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,001 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them