Title |
Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
|
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Published in |
Cancer Cell International, January 2006
|
DOI | 10.1186/1475-2867-6-2 |
Pubmed ID | |
Authors |
Alma Chavez-Blanco, Carlos Perez-Plasencia, Enrique Perez-Cardenas, Claudia Carrasco-Legleu, Edgar Rangel-Lopez, Blanca Segura-Pacheco, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Myrna Candelaria, Gustavo Cabrera, Alfonso Duenas-Gonzalez |
Abstract |
Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of experimental models. The objective of this study was to evaluate the combined antineoplastic effect of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in a panel of cancer cell lines. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 100 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 17% |
Student > Ph. D. Student | 16 | 16% |
Student > Master | 15 | 15% |
Student > Bachelor | 15 | 15% |
Professor | 5 | 5% |
Other | 20 | 20% |
Unknown | 12 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 30% |
Medicine and Dentistry | 25 | 25% |
Biochemistry, Genetics and Molecular Biology | 13 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Neuroscience | 4 | 4% |
Other | 8 | 8% |
Unknown | 15 | 15% |