Title |
Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
|
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Published in |
Molecular Neurodegeneration, December 2017
|
DOI | 10.1186/s13024-017-0232-6 |
Pubmed ID | |
Authors |
Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue |
Abstract |
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that share genetic risk factors and pathological hallmarks. Intriguingly, these shared factors result in a high rate of comorbidity of these diseases in patients. Intracellular protein aggregates are a common pathological hallmark of both diseases. Emerging evidence suggests that impaired RNA processing and disrupted protein homeostasis are two major pathogenic pathways for these diseases. Indeed, recent evidence from genetic and cellular studies of the etiology and pathogenesis of ALS-FTD has suggested that defects in autophagy may underlie various aspects of these diseases. In this review, we discuss the link between genetic mutations, autophagy dysfunction, and the pathogenesis of ALS-FTD. Although dysfunction in a variety of cellular pathways can lead to these diseases, we provide evidence that ALS-FTD is, in many cases, an autophagy disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 99 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 19% |
Student > Bachelor | 13 | 13% |
Student > Master | 11 | 11% |
Researcher | 8 | 8% |
Student > Doctoral Student | 7 | 7% |
Other | 13 | 13% |
Unknown | 28 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 22 | 22% |
Biochemistry, Genetics and Molecular Biology | 19 | 19% |
Medicine and Dentistry | 10 | 10% |
Agricultural and Biological Sciences | 8 | 8% |
Computer Science | 3 | 3% |
Other | 10 | 10% |
Unknown | 27 | 27% |