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Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers

Overview of attention for article published in Genome Biology (Online Edition), December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
86 tweeters

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
177 Mendeley
citeulike
2 CiteULike
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Title
Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers
Published in
Genome Biology (Online Edition), December 2017
DOI 10.1186/s13059-017-1379-8
Pubmed ID
Authors

Robert S. Young, Yatendra Kumar, Wendy A. Bickmore, Martin S. Taylor

Abstract

Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as such has been utilized to experimentally identify active enhancers de novo. Here, we show that bidirectional transcription initiation is a pervasive feature of accessible chromatin, including at enhancers, promoters, and other DNase hypersensitive regions not marked with canonical histone modification profiles. Transcription is less predictive for enhancer activity than epigenetic modifications such as H3K4me1 or the accessibility of DNA when measured both in enhancer assays and at endogenous loci. The stability of enhancer initiated transcripts does not influence measures of enhancer activity and we cannot detect evidence of purifying selection on the resulting enhancer RNAs within the human population. Our results indicate that bidirectional transcription initiation from accessible chromatin is not sufficient for, nor specific to, enhancer activity. Transcription initiating at enhancers may be a frequent by-product of promiscuous RNA polymerase initiation at accessible chromatin and is unlikely to generally play a functional role in enhancer activity.

Twitter Demographics

The data shown below were collected from the profiles of 86 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 1 <1%
France 1 <1%
Unknown 173 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 33%
Researcher 32 18%
Student > Master 17 10%
Student > Bachelor 13 7%
Other 10 6%
Other 25 14%
Unknown 22 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 76 43%
Agricultural and Biological Sciences 56 32%
Computer Science 5 3%
Engineering 4 2%
Physics and Astronomy 2 1%
Other 6 3%
Unknown 28 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2019.
All research outputs
#752,860
of 22,130,231 outputs
Outputs from Genome Biology (Online Edition)
#590
of 4,040 outputs
Outputs of similar age
#22,366
of 446,612 outputs
Outputs of similar age from Genome Biology (Online Edition)
#61
of 241 outputs
Altmetric has tracked 22,130,231 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,040 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.