Title |
Metastatic prostate cancer cell-specific phage-like particles as a targeted gene-delivery system
|
---|---|
Published in |
Journal of Nanobiotechnology, September 2013
|
DOI | 10.1186/1477-3155-11-31 |
Pubmed ID | |
Authors |
Olusegun A Fagbohun, Robert A Kazmierczak, Valery A Petrenko, Abraham Eisenstark |
Abstract |
One of the cardinal requirements for effective therapeutic management of tumors is the selective delivery of cancer drugs to the right site by ligand-decorated nanomedicines. Screening of 2 × 109 clone landscape phage library provides a reliable avenue for generating protein ligands specific for tumor cells. It was shown that selective phage proteins derived from landscape phage libraries against breast and prostate cancer cells are able to navigate drug or siRNA loaded liposomes to corresponding cancer cells with minimal toxicity to non-neoplastic cells. In an alternative platform, glioma cell-specific phage proteins were used for assembling in vivo cancer-specific phage-like particles, named 'phagemid infective particles' as targeted gene-delivery vehicles. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 17% |
Student > Master | 7 | 17% |
Student > Bachelor | 6 | 14% |
Professor > Associate Professor | 5 | 12% |
Researcher | 4 | 10% |
Other | 4 | 10% |
Unknown | 9 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 24% |
Medicine and Dentistry | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Engineering | 2 | 5% |
Chemistry | 2 | 5% |
Other | 6 | 14% |
Unknown | 15 | 36% |