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Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis

Overview of attention for article published in BMC Health Services Research, January 2015
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Title
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis
Published in
BMC Health Services Research, January 2015
DOI 10.1186/s12913-014-0640-z
Pubmed ID
Authors

Bach Xuan Tran, Long Hoang Nguyen, Arto Ohinmaa, Rachel Marie Maher, Vuong Minh Nong, Carl A Latkin

Abstract

BackgroundUtility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by disease stages, and investigate changes in their health utility over the course of antiretroviral treatment.MethodsWe searched PubMed/Medline, Cochrane Database of Systematic Review, NHS Economic Evaluation Database and Web of Science for English-language peer-reviewed papers published during 2000¿2013. We selected 49 studies that used 3 direct and 6 indirect preference based instruments to make a total of 218 utility measurements. Random effect models with robust estimation of standard errors and multivariate fractional polynomial regression were used to obtain the pooled estimates of utility and model their trends.ResultsReliability of direct-preference measures tended to be lower than other types of measures. Utility elicited by two of the indirect preference measures - SF-6D (0.171) and EQ-5D (0.114), and that of Time-Trade off (TTO) (0.151) was significantly different than utility elicited by Standard Gamble (SG). Compared to asymptomatic HIV patients, symptomatic and AIDS patients reported a decrement of 0.025 (p = 0.40) and 0.176 (p = 0.001) in utility scores, adjusting for method of assessment. In longitudinal studies, the pooled health utility of HIV/AIDS patients significantly decreased in the first 3 months of treatment, and rapidly increased afterwards. Magnitude of change varied depending on the method of assessment and length of antiretroviral treatment.ConclusionThe study provides an accumulation of evidence on measurement properties of health utility estimates that can help inform the selection of instruments for future studies. The pooled estimates of health utilities and their trends are useful in economic evaluation and policy modelling of HIV/AIDS treatment strategies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 92 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 22%
Researcher 13 14%
Student > Ph. D. Student 13 14%
Student > Postgraduate 8 9%
Student > Bachelor 7 8%
Other 10 11%
Unknown 22 24%
Readers by discipline Count As %
Medicine and Dentistry 27 29%
Nursing and Health Professions 11 12%
Economics, Econometrics and Finance 6 6%
Psychology 5 5%
Business, Management and Accounting 3 3%
Other 16 17%
Unknown 25 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2015.
All research outputs
#20,251,039
of 22,780,165 outputs
Outputs from BMC Health Services Research
#7,090
of 7,623 outputs
Outputs of similar age
#295,630
of 351,834 outputs
Outputs of similar age from BMC Health Services Research
#69
of 78 outputs
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