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Mendeley readers
| Title |
Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
|
|---|---|
| Published in |
Translational Neurodegeneration, December 2017
|
| DOI | 10.1186/s40035-017-0104-6 |
| Pubmed ID | |
| Authors |
Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy, George D. Mellick |
| Abstract |
In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson's disease (PD). We link the Braak's staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others that interfere with α-syn endocytosis as a means to target the progression of the disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 13% |
| Student > Master | 6 | 13% |
| Student > Ph. D. Student | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Researcher | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 15 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Medicine and Dentistry | 6 | 13% |
| Agricultural and Biological Sciences | 4 | 9% |
| Neuroscience | 4 | 9% |
| Chemistry | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 16 | 35% |