Title |
High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study
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Published in |
Lipids in Health and Disease, October 2011
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DOI | 10.1186/1476-511x-10-181 |
Pubmed ID | |
Authors |
Mary K Wojczynski, Stephen P Glasser, Albert Oberman, Edmond K Kabagambe, Paul N Hopkins, Michael Y Tsai, Robert J Straka, Jose M Ordovas, Donna K Arnett |
Abstract |
Postprandial lipemia (PPL) is likely a risk factor for cardiovascular disease but these changes have not been well described and characterized in a large cohort. We assessed acute changes in the size and concentration of total and subclasses of LDL, HDL, and VLDL particles in response to a high-fat meal. Participants (n = 1048) from the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) Study who ingested a high-fat meal were included in this analysis. Lipids were measured at 0 hr (fasting), 3.5 hr, and 6 hr after a standardized fat meal. Particle size distributions were determined using nuclear magnetic resonance spectroscopy. Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ethiopia | 1 | 20% |
Comoros | 1 | 20% |
United States | 1 | 20% |
Norway | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 80 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 20% |
Student > Ph. D. Student | 11 | 13% |
Student > Master | 10 | 12% |
Student > Bachelor | 7 | 8% |
Other | 6 | 7% |
Other | 11 | 13% |
Unknown | 21 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 20% |
Agricultural and Biological Sciences | 14 | 17% |
Biochemistry, Genetics and Molecular Biology | 11 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Nursing and Health Professions | 3 | 4% |
Other | 10 | 12% |
Unknown | 24 | 29% |