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Morphine reduces local cytokine expression and neutrophil infiltration after incision

Overview of attention for article published in Molecular Pain, October 2007
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Title
Morphine reduces local cytokine expression and neutrophil infiltration after incision
Published in
Molecular Pain, October 2007
DOI 10.1186/1744-8069-3-28
Pubmed ID
Authors

J David Clark, Xiaoyou Shi, Xiangqi Li, Yanli Qiao, DeYong Liang, Martin S Angst, David C Yeomans

Abstract

Inflammation and nociceptive sensitization are hallmarks of tissue surrounding surgical incisions. Recent studies demonstrate that several cytokines may participate in the enhancement of nociception near these wounds. Since opioids like morphine interact with neutrophils and other immunocytes, it is possible that morphine exerts some of its antinociceptive action after surgical incision by altering the vigor of the inflammatory response. On the other hand, keratinocytes also express opioid receptors and have the capacity to produce cytokines after injury. Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 11 19%
Student > Bachelor 8 14%
Student > Ph. D. Student 6 11%
Researcher 5 9%
Student > Master 5 9%
Other 14 25%
Unknown 8 14%
Readers by discipline Count As %
Medicine and Dentistry 13 23%
Agricultural and Biological Sciences 8 14%
Neuroscience 6 11%
Biochemistry, Genetics and Molecular Biology 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 8 14%
Unknown 13 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2016.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Molecular Pain
#190
of 669 outputs
Outputs of similar age
#29,482
of 84,450 outputs
Outputs of similar age from Molecular Pain
#3
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,450 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.