Title |
Morphine reduces local cytokine expression and neutrophil infiltration after incision
|
---|---|
Published in |
Molecular Pain, October 2007
|
DOI | 10.1186/1744-8069-3-28 |
Pubmed ID | |
Authors |
J David Clark, Xiaoyou Shi, Xiangqi Li, Yanli Qiao, DeYong Liang, Martin S Angst, David C Yeomans |
Abstract |
Inflammation and nociceptive sensitization are hallmarks of tissue surrounding surgical incisions. Recent studies demonstrate that several cytokines may participate in the enhancement of nociception near these wounds. Since opioids like morphine interact with neutrophils and other immunocytes, it is possible that morphine exerts some of its antinociceptive action after surgical incision by altering the vigor of the inflammatory response. On the other hand, keratinocytes also express opioid receptors and have the capacity to produce cytokines after injury. Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 11 | 19% |
Student > Bachelor | 8 | 14% |
Student > Ph. D. Student | 6 | 11% |
Researcher | 5 | 9% |
Student > Master | 5 | 9% |
Other | 14 | 25% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 23% |
Agricultural and Biological Sciences | 8 | 14% |
Neuroscience | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Other | 8 | 14% |
Unknown | 13 | 23% |