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Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands

Overview of attention for article published in Genome Biology, October 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

patent
9 patents
wikipedia
11 Wikipedia pages

Citations

dimensions_citation
182 Dimensions

Readers on

mendeley
234 Mendeley
connotea
1 Connotea
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Title
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
Published in
Genome Biology, October 2002
DOI 10.1186/gb-2002-3-11-research0063
Pubmed ID
Authors

Patrick Joost, Axel Methner

Abstract

G-protein-coupled receptors (GPCRs) are the largest and most diverse family of transmembrane receptors. They respond to a wide range of stimuli, including small peptides, lipid analogs, amino-acid derivatives, and sensory stimuli such as light, taste and odor, and transmit signals to the interior of the cell through interaction with heterotrimeric G proteins. A large number of putative GPCRs have no identified natural ligand. We hypothesized that a more complete knowledge of the phylogenetic relationship of these orphan receptors to receptors with known ligands could facilitate ligand identification, as related receptors often have ligands with similar structural features.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Denmark 2 <1%
Spain 2 <1%
Austria 1 <1%
Australia 1 <1%
United Kingdom 1 <1%
Egypt 1 <1%
Belgium 1 <1%
Germany 1 <1%
Other 4 2%
Unknown 216 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 47 20%
Student > Ph. D. Student 41 18%
Student > Master 30 13%
Student > Bachelor 19 8%
Student > Doctoral Student 16 7%
Other 48 21%
Unknown 33 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 76 32%
Biochemistry, Genetics and Molecular Biology 45 19%
Pharmacology, Toxicology and Pharmaceutical Science 22 9%
Chemistry 19 8%
Medicine and Dentistry 18 8%
Other 18 8%
Unknown 36 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2023.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Genome Biology
#2,944
of 4,467 outputs
Outputs of similar age
#8,940
of 50,684 outputs
Outputs of similar age from Genome Biology
#4
of 14 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 50,684 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.