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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

Overview of attention for article published in Genome Biology, December 2005
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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1 Facebook page
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3 Wikipedia pages

Readers on

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84 Mendeley
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1 Connotea
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Title
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart
Published in
Genome Biology, December 2005
DOI 10.1186/gb-2005-6-13-r107
Pubmed ID
Authors

Rong Mao, Xiaowen Wang, Edward L Spitznagel, Laurence P Frelin, Jason C Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J Downey, Jonathan Pevsner

Abstract

Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisomy 21. However, it is unclear whether the entire transcriptome is disrupted, or whether there is a more restricted increase in the expression of those genes assigned to chromosome 21. Also, the statistical significance of differentially expressed genes in human Down syndrome tissues has not been reported.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
France 1 1%
Unknown 82 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 30%
Student > Ph. D. Student 17 20%
Student > Master 12 14%
Student > Bachelor 5 6%
Professor 4 5%
Other 10 12%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 35%
Biochemistry, Genetics and Molecular Biology 11 13%
Medicine and Dentistry 8 10%
Neuroscience 5 6%
Computer Science 2 2%
Other 11 13%
Unknown 18 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2023.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Genome Biology
#3,444
of 4,467 outputs
Outputs of similar age
#43,641
of 171,166 outputs
Outputs of similar age from Genome Biology
#2
of 17 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.