Title |
Cilia in autophagy and cancer
|
---|---|
Published in |
Cilia, February 2016
|
DOI | 10.1186/s13630-016-0027-3 |
Pubmed ID | |
Authors |
Muqing Cao, Qing Zhong |
Abstract |
Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental and degenerative disorders. Interestingly, loss of cilia has been observed in multiple malignant tumors, suggesting a potential suppressive role of cilia in cancer development. More recently, emerging studies began to unveil the bidirectional interaction of cilia and autophagy, a basic cellular clearance and recycling mechanism to regulate cell homeostasis. Here, we summarize the interplay between cilia and autophagy and discuss the roles of cilia in both autophagy and cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 27% |
Student > Master | 15 | 16% |
Researcher | 13 | 14% |
Student > Bachelor | 7 | 8% |
Professor | 6 | 7% |
Other | 15 | 16% |
Unknown | 10 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 32 | 35% |
Agricultural and Biological Sciences | 25 | 27% |
Medicine and Dentistry | 13 | 14% |
Neuroscience | 5 | 5% |
Physics and Astronomy | 1 | 1% |
Other | 3 | 3% |
Unknown | 12 | 13% |