Title |
Strategies for using nanoprobes to perceive and treat cancer activity: a review
|
---|---|
Published in |
Journal of Biological Engineering, March 2017
|
DOI | 10.1186/s13036-016-0044-1 |
Pubmed ID | |
Authors |
Byunghoon Kang, Aastha Kukreja, Daesub Song, Yong-Min Huh, Seungjoo Haam |
Abstract |
Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 25% |
Student > Master | 5 | 18% |
Student > Postgraduate | 2 | 7% |
Student > Doctoral Student | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 4 | 14% |
Unknown | 8 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 5 | 18% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
Engineering | 3 | 11% |
Physics and Astronomy | 1 | 4% |
Other | 1 | 4% |
Unknown | 11 | 39% |