Title |
Time-to-infection by Plasmodium falciparum is largely determined by random factors
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Published in |
BMC Medicine, January 2015
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DOI | 10.1186/s12916-014-0252-9 |
Pubmed ID | |
Authors |
Mykola Pinkevych, Kiprotich Chelimo, John Vulule, James W Kazura, Ann M Moormann, Miles P Davenport |
Abstract |
The identification of protective immune responses to P. falciparum infection is an important goal for the development of a vaccine for malaria. This requires the identification of susceptible and resistant individuals, so that their immune responses may be studied. Time-to-infection studies are one method for identifying putative susceptible individuals (infected early) versus resistant individuals (infected late). However, the timing of infection is dependent on random factors, such as whether the subject was bitten by an infected mosquito, as well as individual factors, such as their level of immunity. It is important to understand how much of the observed variation in infection is simply due to chance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 25% |
Spain | 3 | 19% |
Singapore | 1 | 6% |
United States | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 63% |
Scientists | 4 | 25% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Spain | 1 | 3% |
Mali | 1 | 3% |
Unknown | 32 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 31% |
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Master | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 3 | 9% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 20% |
Medicine and Dentistry | 6 | 17% |
Engineering | 4 | 11% |
Nursing and Health Professions | 2 | 6% |
Immunology and Microbiology | 1 | 3% |
Other | 6 | 17% |
Unknown | 9 | 26% |