Title |
Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ
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Published in |
Journal of Experimental & Clinical Cancer Research, March 2014
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DOI | 10.1186/1756-9966-33-27 |
Pubmed ID | |
Authors |
Jens HW Pahl, Kitty MC Kwappenberg, Eleni M Varypataki, Susy J Santos, Marieke L Kuijjer, Susan Mohamed, Juul T Wijnen, Maarten JD van Tol, Anne-Marie Cleton-Jansen, R Maarten Egeler, Wim Jiskoot, Arjan C Lankester, Marco W Schilham |
Abstract |
In osteosarcoma, the presence of tumor-infiltrating macrophages positively correlates with patient survival in contrast to the negative effect of tumor-associated macrophages in patients with other tumors. Liposome-encapsulated muramyl tripeptide (L-MTP-PE) has been introduced in the treatment of osteosarcoma patients, which may enhance the potential anti-tumor activity of macrophages. Direct anti-tumor activity of human macrophages against human osteosarcoma cells has not been described so far. Hence, we assessed osteosarcoma cell growth after co-culture with human macrophages. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 70 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 19% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Other | 17 | 24% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 18% |
Medicine and Dentistry | 13 | 18% |
Immunology and Microbiology | 10 | 14% |
Agricultural and Biological Sciences | 9 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Other | 9 | 13% |
Unknown | 13 | 18% |