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Genomic insights into Mycobacterium simiae human colonization

Overview of attention for article published in Environmental Microbiome, January 2018
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Title
Genomic insights into Mycobacterium simiae human colonization
Published in
Environmental Microbiome, January 2018
DOI 10.1186/s40793-017-0291-x
Pubmed ID
Authors

José L. Steffani-Vallejo, Marion E. Brunck, Erika Y. Acosta-Cruz, Rafael Montiel, Francisco Barona-Gómez

Abstract

Mycobacterium simiae (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculous Mycobacterium species found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of M. simiae (MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 bp, the genomic sequence of strain MsiGto is the largest of the three M. simiae genomes reported to date. Gene prediction revealed 6409 CDSs in total, including 6354 protein-coding genes and 52 RNA genes. Comparative genomic analysis identified shared features between strain MsiGto and the other two reported M. simiae genomes, as well as unique genes. Our data reveals that M. simiae MsiGto harbors virulence-related genes, such as arcD, ESAT-6, and those belonging to the antigen 85 complex and mce clusters, which may explain its successful transition to the human host. We expect the genome information of strain MsiGto will provide a better understanding of infective mechanisms and virulence of this emergent pathogen.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 24%
Student > Ph. D. Student 3 18%
Student > Master 2 12%
Student > Bachelor 2 12%
Unspecified 1 6%
Other 2 12%
Unknown 3 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 24%
Biochemistry, Genetics and Molecular Biology 2 12%
Unspecified 1 6%
Immunology and Microbiology 1 6%
Psychology 1 6%
Other 2 12%
Unknown 6 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2018.
All research outputs
#15,745,807
of 25,382,440 outputs
Outputs from Environmental Microbiome
#444
of 786 outputs
Outputs of similar age
#248,350
of 449,895 outputs
Outputs of similar age from Environmental Microbiome
#7
of 17 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 786 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,895 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.