Title |
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
|
---|---|
Published in |
BMC Biology, January 2018
|
DOI | 10.1186/s12915-017-0470-7 |
Pubmed ID | |
Authors |
Shiori Sekine, Richard J. Youle |
Abstract |
Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy mitochondrial network, is initiated by activation of the PINK1 kinase specifically on damaged mitochondria. Recent investigation of this process reveals that import of PINK1 into mitochondria is regulated and yields a stress-sensing mechanism. In this review, we focus on the mechanisms of mitochondrial stress-dependent PINK1 activation that is exerted by regulated import of PINK1 into different mitochondrial compartments and how this offers strategies to pharmacologically activate the PINK1/Parkin pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 238 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 46 | 19% |
Student > Bachelor | 36 | 15% |
Student > Master | 30 | 13% |
Researcher | 29 | 12% |
Student > Doctoral Student | 8 | 3% |
Other | 22 | 9% |
Unknown | 67 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 81 | 34% |
Agricultural and Biological Sciences | 33 | 14% |
Neuroscience | 22 | 9% |
Medicine and Dentistry | 12 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 11 | 5% |
Unknown | 72 | 30% |