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The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase

Overview of attention for article published in BMC Molecular and Cell Biology, February 2007
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Title
The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase
Published in
BMC Molecular and Cell Biology, February 2007
DOI 10.1186/1471-2199-8-15
Pubmed ID
Authors

Sara Riccardo, Giuseppe Tortoriello, Ennio Giordano, Mimmo Turano, Maria Furia

Abstract

In eukaryotic cells, each molecule of H/ACA small nucleolar RNA (snoRNA) assembles with four evolutionarily conserved core proteins to compose a specific ribonucleoprotein particle. One of the four core components has pseudouridine synthase activity and catalyzes the conversion of a selected uridine to pseudouridine. Members of the pseudouridine synthase family are highly conserved. In addition to catalyzing pseudouridylation of target RNAs, they carry out a variety of essential functions related to ribosome biogenesis and, in mammals, to telomere maintenance. To investigate further the molecular mechanisms underlying the expression of pseudouridine synthase genes, we analyzed the transcriptional activity of the Drosophila member of this family in great detail.

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Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
France 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 35%
Student > Master 5 22%
Student > Bachelor 3 13%
Student > Ph. D. Student 2 9%
Other 2 9%
Other 1 4%
Unknown 2 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 57%
Biochemistry, Genetics and Molecular Biology 3 13%
Medicine and Dentistry 2 9%
Computer Science 1 4%
Unknown 4 17%