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The role of proopiomelanocortin (POMC) neurones in feeding behaviour

Overview of attention for article published in Nutrition & Metabolism, September 2007
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

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3 news outlets
blogs
3 blogs
twitter
1 X user
wikipedia
7 Wikipedia pages
googleplus
1 Google+ user
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2 YouTube creators

Citations

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250 Dimensions

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418 Mendeley
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Title
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Published in
Nutrition & Metabolism, September 2007
DOI 10.1186/1743-7075-4-18
Pubmed ID
Authors

George WM Millington

Abstract

The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin. The MSHs and ACTH bind to the extracellular G-protein coupled melanocortin receptors (MCRs) of which there are five subtypes. The MC3R and MC4R show widespread expression in the central nervous system (CNS), whilst there is low level expression of MC1R and MC5R. In the CNS, cell bodies for POMC are mainly located in the arcuate nucleus of the hypothalamus and the nucleus tractus solitarius of the brainstem. Both of these areas have well defined functions relating to appetite and food intake. Mouse knockouts (ko) for pomc, mc4r and mc3r all show an obese phenotype, as do humans expressing mutations of POMC and MC4R. Recently, human subjects with specific mutations in beta-MSH have been found to be obese too, as have mice with engineered beta-endorphin deficiency. The CNS POMC system has other functions, including regulation of sexual behaviour, lactation, the reproductive cycle and possibly central cardiovascular control. However, this review will focus on feeding behaviour and link it in with the neuroanatomy of the POMC neurones in the hypothalamus and brainstem.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 418 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 1%
United States 3 <1%
Germany 2 <1%
Austria 2 <1%
France 1 <1%
Brazil 1 <1%
Norway 1 <1%
Korea, Republic of 1 <1%
Chile 1 <1%
Other 0 0%
Unknown 401 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 75 18%
Student > Bachelor 71 17%
Student > Master 60 14%
Researcher 51 12%
Student > Doctoral Student 32 8%
Other 53 13%
Unknown 76 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 107 26%
Neuroscience 62 15%
Biochemistry, Genetics and Molecular Biology 56 13%
Medicine and Dentistry 51 12%
Psychology 12 3%
Other 38 9%
Unknown 92 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2023.
All research outputs
#808,933
of 25,371,288 outputs
Outputs from Nutrition & Metabolism
#136
of 1,014 outputs
Outputs of similar age
#1,223
of 81,071 outputs
Outputs of similar age from Nutrition & Metabolism
#1
of 2 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,014 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,071 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them